BACKGROUND Topical application of glyceryl trinitrate (GTN) ointment heals chronic anal fissures, providing an alternative to the traditional first line treatment of surgical sphincterotomy. AIMS To determine the most effective dose of topical GTN for treatment of chronic anal fissures and to assess long term results. METHODS Seventy consecutive patients with chronic anal fissure, were.. It also found that the anal fissure came back in about half of the people who seemed to be cured with glyceryl trinitrate. No studies were found that looked at how well the 0.2% strength of the glyceryl trinitrate ointment worked compared with the 0.4% ointment in treating chronic anal fissure in children, young people or adults.
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(PDF) Successful use of 0. Glyceryl Trinitrate ointment for anal fissures in Erbil city, Iraq
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Nitric oxide donors such as glyceryl trinitrate (GTN) cause a chemical sphincterotomy leading to healing of the fissure. This study addresses the hypothesis that topical GTN ointment may be an effective nonsurgical treatment for chronic anal fissure. Methods: Thirty-nine consecutive patients (23 women; median age, 34 (range, 16-54) years) with.. PURPOSE: Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence. Reversible chemical sphincterotomy may be achieved by anal application of glyceryl trinitrate ointment (nitric oxide donor), which has.
